Furthermore, although the topic of this review is mitochondria, dysregulation of other organelles such as autophagosome, lysosomes and UPS commonly make contributions for the pathological progress of neurodegenerative diseases
Molecular dockings were performed on AutoDock Vina 1.2.0 software and CB-DOCK2 website 60,61
34 Biofilm formation is another strategy for antibiotic resistance
According to recent statistical data among all COVID-19 patients, ~19% of them were severe or critical, most of which displayed remarkably increased serum levels of pro-inflammatory cytokines and subsets of immune cells ( The Immune Response and CRS in COVID-19 Recent advances in the pathophysiologic understanding of COVID-19 suggests that CRS has a great association with the severity of disease due to increased serum levels of tumor necrosis factor (TNF-), granulocyte-colony stimulating factor (G-CSF), interferon gamma-induced protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1) and macrophage inflammatory protein 1 (MIP1A) ( Initial reports have also determined that a multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 may cause public concern
Most agents undergo proteolytic degradation and renal elimination
